The Swiss Mediscan Syphilis Screen Test (RST) is a qualitative test for the detection of antibodies to T. pallidum in human serum/plasma or whole blood.
Venereal syphilis is a chronic illness brought on by infection with the spirochaete microorganism Treponema pallidum. Infection with the systemic from the start as well as condition is characterized by periods of calm (latency) after over of 20 years. These attributes, along with the fact that T. pallidum could not be conveniently isolated in society, indicate that serological strategies play a major function in the testing of syphilis.
The Swiss Mediscan Syphilis Test (RST) is a qualitative Syphilis test for the detection of Syphilis symptoms antibodies to T. pallidum in human serum/plasma or whole blood.
Throughout very early primary syphilis the first antibodies to show up are class IgM. IgG class antibodies do not reach substantial titers until later in the main stage. As the disease advances into the second phase, T. pallidum antibodies of both IgM as well as IgG courses get to peak rates. Afterwards T. pallidum IgG antibodies will certainly linger indefinitely regardless of the training course of the illness, whereas product degrees of T. pallidum IgM will differ in a fashion, which is closely pertaining to disease task.
If a T. pallidum infection is allowed to progress right into the late phase of the illness, product IgM will certainly remain demonstrable. However, following effective therapy product IgM levels will decrease, ultimately to negativeness. The price of decline varies with the stage at which therapy is commenced, to ensure that syphilis treated during the main phase of the disease will a more rapid IgM decline compared to when it comes to an infection dealt with at a late phase of the condition. Serum IgM levels will generally reveal at least fourfold decline within 3-4 months following treatment. The time to finish negativity will rely on the sensitivity of the assay in operation, but is normally less than 24 months.